Global Next Generation Sequencing for Non-invasive Prenatal Testing Market 2023″ report provides 360° view on Industry by shading light on all major factors like Key Players, Demand for Products, End User & Applications, Future Growth & Forecast.
Non-Invasive Prenatal Testing (NIPT) is a type of testing method which is used to screen pregnancy for the risk of being affected with the most common chromosomal conditions such as Trisomy 21 (Down’s Syndrome), Trisomy 18 (Edwards Syndrome) and Trisomy 13 (Patau Syndrome). It is available to all pregnant women from 9 to 10 weeks of gestation, who are at both low-risk and high-risk for chromosomal aneuploidies. This test carries no risk of miscarriage and it is the most accurate screening test. The detection rate is more than 99% accurate.
NIPT is performed on a blood sample of the pregnant woman. The cell-free fetal DNA (cffDNA) which exceeds 4% of all the cell-free DNA in nearly all women from 10 weeks onward is collected and analyzed using next generation sequencing technology, coupled with advanced bioinformatics analysis. In addition to screening for common chromosomal trisomy conditions, few NIPT tests offer analysis of the X and Y sex chromosomes and gender identification. NIPT also screens for the risk of sex aneuploidy conditions including Turner’s (Monosomy X), Klinefelter (XXY) and Triple-X (XXX).
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The companies/laboratories currently offering NIPT screening across the world include:
– Ariosa (USA): Harmony.
– BGI Health (China): NIFTY.
– Illumina (USA): Verifi.
– Natera (USA) Panorama.
– Premaitha (UK): IONA.
– Sequenom (USA): MATERNIT21 PLUS.
Several NIPT methods have been developed based on recent advances in molecular biology and sequencing technologies. Recently, shotgun massively parallel sequencing (s-MPS) method is being commonly used for sequencing of DNA, after isolation and amplification of the cfDNA, which is followed by mapping the sequences to their chromosome and comparing the results.
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NIPT was first launched by commercial providers in the United States and China (Hong Kong) in 2011. It quickly moved into markets in Western Europe, the Middle East, South America, Asia and Africa, with samples from many of these countries being sent to the United States or China for testing. Studies show that adoption in developed countries is high and has significantly reduced the number of invasive tests performed.
Although NIPT is currently available through private providers, it is not yet widely available in publicly funded prenatal services. During the forecast period it is expected that even public service providers will adopt this test at a high rate.
Advantages offered by NIPT such as non-invasiveness, high accuracy and early detection. Coupled with raising awareness, increasing market penetration in Asia and Latin America and increase in average maternal age are the major factors expected to drive the growth of the global NIPT market during the forecast period.
Companies Mentioned:
- 10X GENOMICS
- 23ANDME
- AGILENT TECHNOLOGIES, INC.
- Annoroad
- BERRY GENOMICS
- BGI (Beijing Genomics Institute)
- Eurofin GATC – Lifecodexx AG
- Eurofins Gatc Biotech
- ILLUMINA INC.
- Knome, Inc. / Tute Genomics / Pierian Dx
- LABCORP
- Labcorp-sequenom Laboratories
- NATERA, INC.
- NIPD GENETICS
- OXFORD NANOPORE TECHNOLOGIES LTD.
- Pacific Biosciences Of California
- PERKINELMER, INC.
- Pieriandx, Inc.
- PREMAITHA HEALTH PLC
- QIAGEN NV
- ROCHE HOLDING AG
- THERMO FISHER SCIENTIFIC INC.
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Table of Content
Chapter 1 Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources
Intended Audience
Methodology
Geographic Breakdown
Analyst’s Credentials
Related BCC Research Reports
Chapter 2 Summary and Highlights
Chapter 3 Next Generation Sequencing Overview
Technology Background
Structure and Importance of DNA
Genetic Variation and Analysis
Types of Genetic Variation
Genetic Analysis Technologies
DNA Sequencing Technologies
Whole Genome Sequencing
Targeted Resequencing
ChIP Sequencing
RNA Sequencing
Methylation Sequencing
History of DNA Sequencing
Sanger Sequencing
Introduction to Next-Generation Sequencing (NGS)
Roche 454 Pyrosequencing
Illumina Next-Generation Sequencing
Thermo Fisher Scientific (Life Technologies) NGS
Sequencing Instruments
Benchtop Sequencers
Informatics Technologies
Factors driving NGS Market
Improvements in Clinical NGS Informatics
Growing Need for Better Diagnostics as Part of Molecular Diagnostics Trend
Shift towards Precision Medicine
Factors Restraining NGS Market
Lack of reimbursement coverage and coding
Other Clinical Sequencing Technology Challenges
Chapter 4 Next Generation Sequencing Applications
Drug Discovery/Personalized Medicine
Agriculture and Animal Research
Infectious Diseases/Diagnostics
Genetic Screening
Cancer
Cardiovascular Diseases
Food-Borne Illness
HLA-Typing
Immune Diseases
Metabolic Diseases
Neurological Disorders
Mendelian Disorders
Infectious Diseases
Reproductive Health
Chapter 5 Next Generation Sequencing Based Non-Invasive Prenatal Testing
NIPT-Introduction and Technology Overview
Other Conventional Prenatal Testing Methods
Advantages of NIPT
Positive Predictive Value
Implementation of NIPT Process
In-House Testing
As a Service
Factors Driving NIPT Market
Average Risk NIPT
Favorable Reimbursement
New Advances in Genomic Technologies
Preference for Non-invasive Techniques Over Invasive Methods
Patient Counseling and Awareness
Increasing Collaborations with Local Entities
Increasing Mean Maternal Age
Restraints
Legal and regulatory issues
Access to the Advancing Technologies
Fetal Cell NIPT Industry
Current Market Scenario
Cost of NIPT
Chapter 6 Market Breakdown by NIPT Methods
NGS-based NIPT
NGS Sequencers for NIPT
VeriSeq NIPT Solution
MiSeqDx
NextSeq 550x
NextSeq 550AR
Non-Invasive Prenatal Tests Available in Market
NIFTY
Verifi Prenatal Test
Panorama
MaterniT21
IONA Test
Bambni Test
InformaSeq
Prena Test
VisibiliT
Veracity
Chapter 7 NGS-NIPT End Users
By Disease Area
Down’s Syndrome
Edwards Syndrome (Trisomy 18)
Patau syndrome (Trisomy 13)
Turner Syndrome
Others
By Healthcare Setting
Diagnostic laboratories
Hospitals
Chapter 8 Market Breakdown by Region
North America
USA
Europe
Asia-Pacific
Rest of the World
Chapter 9 Patent Review
Patent Review by Year
Chapter 10 Analysis of Market Opportunities
Market Share Analysis
PEST Analysis
Political
Economical
Social
Technological
Chapter 11 Competitive Landscape
Mergers and Acquisitions
New Product Launches
Agreements, Collaborations, and Partnerships
Chapter 12 Company Profiles
10X GENOMICS
Business Overview
Financials
Products and Services
23ANDME
Business Overview
Products and Services
AGILENT TECHNOLOGIES, INC.
Business Overview
Financials
Products and Services
Business Highlights
ANNOROAD
Business Overview
Products and Services
BERRY GENOMICS
Business Overview
Products and Services
BGI (BEIJING GENOMICS INSTITUTE)
Business Overview
Products and Services
Business Highlights
EUROFINS GATC BIOTECH
Business Overview
EUROFIN GATC – LIFECODEXX AG
Business Overview
Products and Services
Business Highlights
ILLUMINA INC.
Business Overview
Financials
Products and Services
Business Highlights (2017-2018)
KNOME, INC. / TUTE GENOMICS / PIERIAN DX
Business Overview
PIERIANDX, INC.
Products and Services
LABCORP-SEQUENOM LABORATORIES
Business Overview
LABCORP
Business Overview
Labcorp’s Businesses
Financials
Products and Services
NATERA, INC.
Business Overview
Financials
Products and Services
Business Highlights
NIPD GENETICS
Business overview
OXFORD NANOPORE TECHNOLOGIES LTD.
Business Overview
Financials
Products and Services
PACIFIC BIOSCIENCES OF CALIFORNIA
Business Overview
Financials
Products and Services
Business Highlights
PERKINELMER, INC.
PREMAITHA HEALTH PLC
Business Overview
Financials
Products and Services
Business Highlights
QIAGEN NV
Business Overview
Financials
Net Sales by Geographic Region
Products and Services
Business Highlights
ROCHE HOLDING AG
Business Overview
Financials
Products and Services
Historic Mergers and Acquisitions
THERMO FISHER SCIENTIFIC INC.
Business Overview
Financials
Products and Services
Business Highlights
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