Helicobacter is a spiral shaped gram-negative bacteria, causing chronic inflammation and infection in the stomach and duodenum leading to ulceration. H. pylori is found in 50-80% of patients with gastric ulcers and in 90% of patients with duodenal ulcers. H. pylori is expected to eventually develop peptic ulcer disease. Abdominal discomfort as occasional, whereas, major symptoms includes abdominal pain, peptic ulcer, bad breath, etc.
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Helicobacter infection can be diagnosed by invasive gastric mucosal specimens, which are obtained by endoscopy and used for biopsy or non-invasive tests. Invasive tests include immunoassay, rapid urease test, and histology non-invasive includes stool antigen assays serology tests and urea breath test.
Prevalence of helicobacter pylori is declining in developed countries, while its prevalence in emerging economies is increasing. For instance, according to the Faculty of Medicine of the Chinese University of Hong Kong (CUHK), 2017, around 4.4 billion people are infected with Helicobacter pylori (H. pylori). Furthermore, prevalence in Africa is up to 80%, which is the highest globally, while in Asia, over 50% of the population infected with H. pylori. Moreover, according to the International Agency for Research on Cancer Report 2014, in 2012, around 952,000 new gastric cancer cases occurred globally and around 734,000 gastric cancers were estimated to occur due to H. pylori infection. Helicobacter pylori in Africa and Asia is expected to be the regional helicobacter market growth.
The limitations associated with diagnostic tests are expected to be a major factor in the restraining growth of the Helicobacter pylori diagnostics market. For instance, serology-based assays have low sensitivity and specificity, as they are unable to differentiate between active infection and IgG antibodies.
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Key vendors:
Thermo Fisher Scientific, Inc., Bio-Rad Laboratories Inc., Diasorin SPA, Quidel Corporation, F. Hoffmann-La Roche Ltd. (Ventana Medical Systems, Inc.), Meridian Bioscience, Inc., Exalenz Bioscience Ltd., Abbott Laboratories Cardinal Health, Inc. and Halyard Health, Inc.
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